C (3-6 months) Mouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, Mouse Spred1 genomic DNA Neurobiology Research 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Exp. Med., 201, 73-82 (2005).<br>研究成果の公表にあたって謝辞の表明を必要とする。 B6.Cg-Spred1<tm1Hiin> B6.Cg-Spred1<tm1Hiin> Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Spred1 KO, B6-Spred1 KO Spred1 KO, B6-Spred1 KO 吉村　昭彦 九州大学生体防御医学研究所・吉村昭彦先生。 Spred1遺伝子のノックアウトマウス。エクソン4の大部分をPGK-neoカセットで置換。ホモマウスは気道過敏症、好酸化球増加、曲尾 (kinked) 、短顔、空間学習記憶異常、CNS伝達異常を呈す。 Spred1 gene knockout mice. Most of exon 4 was replaced with a PGK-neo cassette. Homozygous mutant mice exhibit impaired spatial learning and memory, shortened head and kinked tail, and abnormal eosinophil physiology and increased airway responsiveness. C（3〜6か月） RBRC05758 Developmental Biology Research Akihiko YOSHIMURA Heterozygote x Wild-type [C57BL/6JJcl] Heterozygote x Wild-type [C57BL/6JJcl] In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp. Med., 201, 73-82 (2005).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Developed by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University. true